Estrogenic Estrace cream is intended for external use to treat and prevent postmenopausal osteoporosis and symptoms of climacteric syndrome. Against the background of Estrace Cream use symptoms, such as hot flashes, increased sweating, depressed mood, vaginal dryness are significantly decreased. The drug also contributes to the reduction of total cholesterol concentration and inhibits the decrease in bone density which occurs during menopause.

Estradiol is active substance of Estrace, in application of the cream on the skin it immediately and almost completely gets into the systemic circulation, while a small its amount is retained in subcutaneous fat and then gradually released into the systemic circulation.

Advantage of Estrace cream over oral forms of the same drug is that it can provide a higher level of estradiol concentrations in the plasma due to the fact that during external use, active substance of the drug is not subject to the effect of “first pass”.

Estrace cream is prescribed for external use in continuous or cyclic mode in doses and for a period that should be individually established for each patient.

A thin layer of Estrace Cream is applied up to the total absorption on the skin of the abdomen, the forearm, shoulder and lower back. Area of application should be not less than the area of two palms otherwise, if the area is too small, the drug will be absorbed longer than 2-3 minutes.

Estrace cream should be applied on the clean skin once a day, in the morning or in the evening, avoiding its contact with the mucous membrane of the vagina and vulva, as well as the breast. The drug does not stain clothes.

Estrace Cream possesses side effects that as a rule, are mildly pronounced and observed only in the first months of the drug use, they are the following: dizziness, headache, mood changes, migraine, increase and sensitivity of the mammary glands, increased libido, menorrhagia, breast tumor, intermenstrual “spotting” discharges, hyperemia and irritation of the skin, peripheral edema, increase in blood pressure, intolerance to contact lenses, changes in body weight.